Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation
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چکیده
منابع مشابه
Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
In cells exposed to ionizing radiation (IR), double-strand breaks (DSBs) form within clustered-damage sites from lesions disrupting the DNA sugar-phosphate backbone. It is commonly assumed that these DSBs form promptly and are immediately detected and processed by the cellular DNA damage response (DDR) apparatus. This assumption is questioned by the observation that after irradiation of naked D...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2004
ISSN: 1362-4962
DOI: 10.1093/nar/gkh306